Expires on: 05/24/2024
The aim of this project is to establish a human-based in vitro platform that comprehensively replicates the journey of cancer cells from the lungs to the brain. This platform will be instrumental in addressing three pivotal questions: (1) What is the mechanism by which cancer metastasizes to the brain? (2) What role does the blood-brain barrier (BBB) play in cancer metastasis to the brain? and (3) How and when can we effectively treat cancer metastasis? By creating a physiologically relevant human cell-based model, META-BRAIN will, for the first time, delineate the entire cascade of cancer metastasis and enable the exploration of novel target proteins at the blood-tumor barrier (BTB). Additionally, this model will serve as the foundation for developing innovative shuttle systems designed for drug delivery to the brain.
Qualifications
- A PhD in a relevant field (e.g. bioengineering, molecular biology, neuroscience, biophysics, etc.)
- Strong knowledge of stem cell biology, particularly in the context of endotelial and neural differentiation and maturation
- Experience with culturing and manipulating stem cells, particularly human-derived cells
- Knowledge of neurobiology and the structure and function of the brain
- Experience with imaging and electrophysiology techniques
- Strong analytical and problem-solving skills
- Excellent verbal and written communication skills
- A record of peer-reviewed publications