Expires on: 5/1/2024
Description
The Institute of Microbiology at ETH Zürich, Switzerland, invites applications for a fully funded PhD position to study the cellular infection biology of Salmonella diarrhea. The project, led by Prof. Wolf-Dietrich Hardt, aims to establish an in vitro gut epithelium infection model that closely mimics real infection scenarios. The research will focus on understanding the molecular and cellular processes driving gut tissue infection, inflammasome activation, and the extrusion of infected enterocytes caused by Salmonella Typhimurium.
Salmonella Typhimurium is a widespread cause of diarrhea, leading to significant morbidity globally. Lacking effective vaccines and therapies, this PhD project seeks to bridge gaps in understanding by establishing an in vitro gut epithelium infection model. The optimized setup will be used to investigate the Type III secretion system 1, translocated effector proteins’ impact on enterocytes, and the host’s innate immune defense. The project is fully funded by the Swiss National Science Foundation (NRP79), providing a unique opportunity for impactful research.
The selected PhD student will benefit from the Hardt lab’s expertise in Salmonella infection models, collaboration networks at ETH Zurich, NCCR Microbiomes, and global partners. The Life Science Zurich Graduate School will offer additional networking and technical support opportunities
Qualifications
- Candidates with a background in microbiology, cellular biology, or related fields are encouraged to apply.
- Previous experience with primary tissue culture models, fluorescence microscopy, FACS, cell biology, and infectious agents would be advantageous.
- However, skills can be developed during the project, making it suitable for motivated individuals eager to contribute to cutting-edge research.
Application
Interested candidates should contact Prof. Wolf-Dietrich Hardt via email at hardt@micro.biol.ethz.ch. The application should include a resume, cover letter, and any relevant supporting documents.